Fenbendazole is an anthelmintic drug used to treat parasites and worms in dogs, cats, rabbits, sheep, goats, horses, and other animal species (trade names include Panacur and Safe-Guard). It is also being used in the Joe Tippens Protocol, a cancer treatment method that uses a combination of anthelmintics and chemotherapy.
A small amount of fenbendazole is excreted in the urine, so the medication is not usually eliminated entirely by the body. However, if your pet has liver or kidney disease, your veterinarian may need to decrease the dosage for safety reasons.
The benzimidazole anthelmintic drugs in the fenbendazole family (including albendazole and metronidazole) act by inhibiting tubulin dimer polymerization, which is involved in microtubules that give structure to cells. This is why fenbendazole can kill parasites, but does not affect normal human cells (which have much higher IC50 values than cancer cell microtubules).
Some people develop stomach pain or diarrhea from taking too much fenbendazole for too long, especially in those with liver or kidney problems that cause low blood flow to the gastrointestinal tract. A few people have a rare side effect of a symptomatic increase in liver enzymes, which is also easily fixed by discontinuing the medicine for a few weeks.
Despite this, fenbendazole has a very good track record of safety in humans. It has been used in thousands of people since it was first discovered to have anti-cancer properties in laboratory experiments in 2002. fenbendazole capsules